Namely, they used sequencing data from eight tissues of the embryonic mouse like heart, lung, brain, or liver. They achieved this by training a statistical model with existing experimental data, telling it which enhancer is active in which tissue. The researchers developed a program that is able to identify DNA sequences that are recognized by the cell in order to activate genes in a tissue-specific way. “We wanted to see how far this approach would take us and test its limits,” says Vingron. According to the prevailing theory, transcription factor proteins recognize “codewords” in enhancers that are specific for a certain cell type, allowing the genome to tell a cell’s story by jumping to the right chapters. “Today, researchers assume that all the information is in the DNA sequence, including information for specific cell types, tissues, and organs,” says Martin Vingron, Director at the Max Planck Institute for Molecular Genetics.
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With a series of statistical and bioinformatic analyses, the scientists identified several hundreds of tissue-specific DNA subsequences or “codewords” in enhancers that guide transcription factors, not only confirming sequences already known from other studies, but also identifying many new ones. Researchers Philipp Benner and Martin Vingron from the Max Planck Institute for Molecular Genetics set out to decipher the instructions of the activation patterns in distinct cell types and embryonic tissues of the mouse. In some cases, they are located far away from the gene they activate.
They attract transcription factor proteins that start the expression of genes, thereby “enhancing” their activity. Sequences called enhancers play an outstanding role in this process.
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By telling the right story at the right time, our genome even manages to give rise to hundreds of different cell types with characteristic life stories breathing an individual identity into every cell.ĭNA snippets scattered across the genome harbor the code that directs the script of a cell’s life, successively switching genes on and off. Researchers from the Max Planck Institute for Molecular Genetics in Berlin now tested how much information can be extracted from sequence data to predict which gene is active in which tissue.Ī good storyteller knows exactly which anecdotes will bring his stories’ characters to life. Save that card and the uniform will show up.How do cells know when to activate a certain gene? This information is encoded in the sequence of the DNA, but our understanding of this code is incomplete. Encrypt your jg2e01_00_00.pp, load AA2Edit, and create a new character. def00.png is the default male and def01.png is the female one. Open jg2e01_00_00.pp in AA2Edit/Data folder by using AA2Decrypt.exe or SB3Utility.ģ. Export the character wearing the uniform you want in JG2ChrData or ReiEditAA2. IMPORTANT: This method only works for average body height and standard uniform.ġ. After the UVs were rendered, the dimensions of the UV could be extrapolated to find the approximate proportion required to work at: Approximately 1:3.25Ĭreating a checker pattern in GIMP at 2048圆722, it was downscaled to 512x458 in Avisynth with Spline64 and overlaid on top of a random pattern.Recommendations are to create your skirt patterns at some resolution according to the proportion like 2048圆700 and downscale to 512x458 using whatever image processing application you have on hand. The UVs were then unwrapped and scaled lengthwise and heightwise so that the proportions of the UV roughly matched the proportions of the skirt in the viewport. To find the rough proportions of the skirt, the skirt was exported as an.
In order to create a more perfect skirt pattern, the pattern must first be created at an initial working resolution based on some proportion, and then downscaled. However, since the skirt has been made to fit in a 512x512 box, there is some distortion. Fortunately, the UVs of the skirt make it fairly easy to create patterns without having to worry too much about warping it's nothing more than strips of rectangles. There isn't really a way to create a texture without warping, except by painting directly onto the polygons using a 3D modeling package. Checker patterns are often used in 3DCG to visually display how well a UV is made
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